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Target intelligence / Profile preview
Interleukin 27 Receptor (None)
- Target
- None
- Molecular classification
- Receptor, Cytokine Receptor, Type I cytokine receptor
01
Overview
The Interleukin 27 receptor (IL-27R) is a cell-surface receptor complex that mediates the biological effects of interleukin-27 (IL-27), a heterodimeric cytokine belonging to the IL-12 family. The IL-27R complex consists of two subunits: IL-27Rα (also known as WSX-1 or TCCR) and gp130. This receptor is expressed on various immune cells, including T cells, B cells, monocytes, macrophages, and dendritic cells. Upon binding to its ligand IL-27, the receptor activates several intracellular signaling pathways, including JAK/STAT, MAPK, and NF-κB. It plays a crucial role in regulating T-helper cell differentiation, modulating innate immunity, and maintaining immune homeostasis. Due to its dual pro-inflammatory and anti-inflammatory properties, it has become an attractive target for therapeutic intervention in autoimmunity and cancer immunotherapy.
- Other names
- IL-27RIL27RIL-27 receptor complex
02
Mechanism of action
Blocking IL-27 binding and downstream signaling
03
Biological functions
Signal transductionRegulation of T-helper cell differentiationModulation of innate immunityImmune homeostasisJAK/STAT pathway activationMAPK pathway activationNF-κB pathway modulation
04
Disease associations
AutoimmunityCancerInflammation
05
Safety considerations
Potential for disrupting immune homeostasis leading to unintended consequences
06
Interacting drugs
Antagonist antibodies targeting IL-27R
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