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Target intelligence / Profile preview
Interleukin 29 Receptor
- Molecular classification
- Receptor, Cytokine Receptor, Class II Cytokine Receptor
01
Overview
The Interleukin 29 receptor is a heterodimeric cell surface receptor complex composed of IFNLR1 (IL28Rα) and IL10RB subunits. It mediates the biological effects of interleukin-29 (IL-29), also known as interferon lambda 1 (IFN-λ1). Upon binding to IL-29, the receptor activates the JAK/STAT signaling pathway, leading to the upregulation of interferon-stimulated genes (ISGs) and subsequent antiviral and immunomodulatory effects. It is primarily expressed on epithelial cells, hepatocytes, and dendritic cells. The receptor plays a role in antiviral defense, immunoregulation, and can have context-dependent effects in cancer and bone homeostasis. Mutations in IFNLR1 can lead to immune dysregulation.
- Other names
- IFNLR1/IL28RA & IL10RBIFNLR1IL28RαCRF2-12LICRIL10R2IL10RBCRF2–4
02
Mechanism of action
Agonist
03
Biological functions
Signal transductionAntiviral responseImmunoregulationJAK/STAT signaling
04
Disease associations
Viral infectionsAutoimmune diseasesCancerBone disease
05
Safety considerations
Immune dysregulation due to impaired signaling
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