Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Interleukin-3 (IL-3)
- Target
- IL-3
- Molecular classification
- Cytokine, Interleukin, Growth Factor
01
Overview
Interleukin-3 (IL-3) is a pleiotropic cytokine that regulates the production, proliferation, differentiation, and survival of various blood cell types. It is primarily secreted by activated T lymphocytes, mast cells, and osteoblastic cells. IL-3 binds to its heterodimeric receptor (CD123/CD131) and activates intracellular signaling pathways such as Ras-Raf-MEK/ERK and JAK/STAT, leading to gene expression changes that promote cell survival and drive proliferation/differentiation in target lineages.
- Other names
- Multi-CSFMulti-Colony Stimulating Factor
02
Mechanism of action
Stimulates proliferation and differentiation of hematopoietic stem cells through receptor binding and activation of intracellular signaling pathways (Ras-Raf-MEK/ERK, JAK/STAT).
03
Biological functions
HematopoiesisCell proliferationCell differentiationCell survivalImmune responseInflammation
04
Disease associations
Bone marrow failureInflammationHematopoietic malignanciesImmunodeficiency
05
Safety considerations
Potential for cytokine stormUncontrolled proliferation of hematopoietic cellsOff-target effects due to pleiotropic activity
Beyond the preview
Go deeper on Interleukin-3 (IL-3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Interleukin-3 (IL-3).