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Target intelligence / Profile preview
Interleukin 3 Receptor (IL-3R)
- Target
- IL-3R
- Molecular classification
- Receptor, Type I cytokine receptor
01
Overview
The interleukin-3 receptor (IL-3R), also known as CD123, is a cell surface receptor that mediates the biological effects of interleukin-3 (IL-3), a cytokine crucial for hematopoiesis and immune regulation. IL-3R is part of the type I cytokine receptor family and functions as a heterodimer composed of a unique alpha chain (IL3RA/CD123) and a common beta subunit (CD131). It is a therapeutic target in certain leukemias, particularly AML and BPDCN.
- Other names
- CD123IL3RA
02
Mechanism of action
Tyrosine kinase signaling induction upon IL-3 binding
03
Biological functions
Signal transductionCell proliferationCell differentiationHematopoiesisImmune response
04
Disease associations
CancerBlastic plasmacytoid dendritic cell neoplasm (BPDCN)Acute Myeloid Leukemia (AML)
05
Interacting drugs
Tagraxofusp
2 more in the full profile.
06
Biomarkers
CD123 expression level in AML blastsIL-3R expression
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