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Target intelligence / Profile preview
Interleukin-3 Receptor Alpha Subunit (IL3RA)
- Target
- IL3RA
- Molecular classification
- Type I cytokine receptor, Cell surface receptor, Single-pass type I transmembrane glycoprotein
01
Overview
Interleukin-3 receptor alpha subunit (IL3RA), also known as CD123, is a cell surface glycoprotein that forms part of the heterodimeric receptor complex for interleukin-3 (IL-3). It is a member of the type I cytokine receptor family and plays a critical role in hematopoietic cell signaling, proliferation, survival, and differentiation. It is a therapeutic target in AML and BPDCN.
- Other names
- CD123IL3RIL3RYIL3RAYhIL-3Ra
02
Mechanism of action
Tagraxofusp: Fusion protein of IL-3 and diphtheria toxin, targets and kills CD123-expressing cells. SGN-CD123A: Antibody-drug conjugate, delivers cytotoxic payload to CD123-expressing cells.
03
Biological functions
Signal transductionCell proliferationCell survivalCell differentiationHematopoiesisImmune response regulation
04
Disease associations
Acute Myeloid Leukemia (AML)Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)Acute Lymphoblastic Leukemia
05
Safety considerations
On-target, off-tumor toxicity to normal hematopoietic cellsCytokine release syndromeInfusion reactions
06
Interacting drugs
Tagraxofusp
1 more in the full profile.
07
Biomarkers
Diagnosis of AMLDiagnosis of BPDCNMonitoring treatment response in CD123-positive malignancies
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