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Target intelligence / Profile preview
Interleukin 3 Receptor Beta Chain (βc)
- Target
- βc
- Molecular classification
- Type I Cytokine Receptor, Receptor subunit
01
Overview
The interleukin-3 receptor beta chain (βc), also known as CD131, is a common signaling subunit shared by the receptors for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-5 (IL-5). It is essential for signal transduction upon ligand binding, leading to downstream activation of pathways such as JAK/STAT, and plays a crucial role in hematopoiesis and immune regulation. Aberrant signaling through this pathway contributes to various diseases, including leukemia, making it a potential therapeutic target, often indirectly targeted through alpha subunits of the respective receptors.
- Other names
- CD131Common Beta ChainIL-3RβCSF2RB protein
02
Mechanism of action
Forms heterodimeric receptor complex with IL-3Rα, GM-CSFRα, or IL-5Rα; intracellular domain activates JAK/STAT signaling pathways upon ligand binding.
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalHematopoiesisImmune response
04
Disease associations
LeukemiaAcute Myeloid Leukemia (AML)Hematopoietic malignancies
05
Safety considerations
Broad expression may limit therapeutic window for direct targeting.Targeting may affect multiple cytokine signaling pathways.
06
Interacting drugs
Tagraxofusp (indirectly, via CD123)
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