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Target intelligence / Profile preview
Interleukin 3 Receptor Beta Subunit (βc)
- Target
- βc
- Molecular classification
- Type I cytokine receptor family, Receptor subunit
01
Overview
The interleukin-3 receptor beta subunit (βc/CD131) is a critical component of the high-affinity receptor complex for interleukin-3 (IL-3), GM-CSF, and IL-5. It functions as a signal transduction subunit, activating intracellular kinases like JAK2 upon ligand engagement. Aberrant activation contributes to malignancies, making it a therapeutic target.
- Other names
- Common beta-chainCD131CSF2RB
02
Mechanism of action
Tagraxofusp: CD123 (IL3RA) targeting fusion protein; Antibody-drug conjugates (experimental): Targeting components of IL-3R pathway
03
Biological functions
Signal transductionCell proliferationCell differentiationHematopoiesisImmune responseAnti-apoptosis
04
Disease associations
Acute Myeloid Leukemia (AML)Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)Cancer
05
Safety considerations
Aberrant activation can contribute to malignancies
06
Interacting drugs
Tagraxofusp
07
Biomarkers
CD123 (IL3RA) expression in AML leukemic stem cells
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