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Target intelligence / Profile preview
Interleukin 3 Receptor Subunit Alpha (CD123)
- Target
- CD123
- Molecular classification
- Type I cytokine receptor, Single-pass type I membrane protein
01
Overview
CD123, or Interleukin 3 Receptor Subunit Alpha, is a type I cytokine receptor that forms a heterodimeric complex with CD131. It mediates the effects of interleukin-3 by initiating downstream signaling pathways. It is expressed on hematopoietic progenitor cells, basophils, and dendritic cells, and is notably overexpressed in AML cells, making it a target for cancer therapy.
- Other names
- IL3RAIL3RIL3RAYIL3RXhIL-3Ra
02
Mechanism of action
Tagraxofusp: Fusion protein combining human IL-3 with diphtheria toxin. SGN-CD123A: Antibody-drug conjugate targeting CD123.
03
Biological functions
Signal transductionGrowth regulationCell proliferationCell survivalHematopoietic cell differentiationImmune response
04
Disease associations
Acute Myeloid Leukemia (AML)Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
05
Safety considerations
Potential for off-target effects due to IL-3 receptor expression on normal cells
06
Interacting drugs
Tagraxofusp
1 more in the full profile.
07
Biomarkers
CD123 expression level in AML blasts
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