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Target intelligence / Profile preview
Interleukin 31 (IL-31)
- Target
- IL-31
- Molecular classification
- Cytokine, gp130/IL-6 cytokine family
01
Overview
Interleukin 31 (IL-31) is a cytokine primarily produced by activated CD4+ T lymphocytes, especially T helper 2 (TH2) cells. It signals through a heterodimeric receptor complex composed of IL-31 receptor A (IL-31RA) and Oncostatin M receptor beta (OSMRβ), activating JAK/STAT, PI3K/AKT, and MAPK pathways. IL-31 plays a key role in immune modulation, neuroimmune communication (inducing itch), and tissue effects in the skin, lungs, and intestines. It is clinically significant in diseases like atopic dermatitis and prurigo nodularis, and therapeutic targeting of IL-31 or its receptor has shown promise in reducing pruritus.
02
Mechanism of action
Monoclonal antibodies targeting IL-31 or its receptor
03
Biological functions
Immune modulationNeuroimmune communicationRegulation of hematopoiesisFacilitates cell-mediated immunityRegulates hematopoietic progenitor cell homeostasis
04
Disease associations
Atopic dermatitisPrurigo nodularisAsthmaAllergic rhinitisInflammatory bowel disease
05
Safety considerations
Sustained overexpression leads to increased sensitivity/pruritusPotential for immune suppressionNeed for careful monitoring of inflammatory responses
06
Interacting drugs
Lokivetmab
07
Biomarkers
Elevated IL-31 levels in lesional skinmRNA levels in lesional skin
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