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Target intelligence / Profile preview
Interleukin-31 receptor (IL-31R)
- Target
- IL-31R
- Molecular classification
- Type I cytokine receptor, Receptor, Heterodimeric receptor
01
Overview
The interleukin-31 receptor (IL-31R) is a heterodimeric cell surface receptor complex composed of IL-31RA and OSMRβ. It is the functional signaling unit for interleukin 31 (IL-31). Upon IL-31 binding, the JAK/STAT, PI3K/AKT, and MAPK pathways are activated, mediating various cellular responses including inflammation and pruritus. The receptor is expressed on epithelial cells, sensory neurons, and immune cells, and is implicated in atopic dermatitis, other chronic skin diseases, inflammatory bowel disease, airway hypersensitivity disorders, and cancer.
- Other names
- IL-31RA (Interleukin 31 receptor alpha)OSMRβ (Oncostatin M receptor beta)
02
Mechanism of action
JAK/STAT pathway activation, PI3K/AKT pathway activation, MAPK cascade activation
03
Biological functions
Signal transductionImmune response regulationInflammation modulationPruritus inductionRegulation of hematopoietic progenitor cell homeostasisNeuroimmune communication
04
Disease associations
Atopic dermatitisChronic skin diseasesInflammatory bowel diseaseAirway hypersensitivity disordersCancerPruritic dermatosesAsthma/allergy
05
Safety considerations
Modulation of immune responsesPotential for off-target effects due to shared OSMRβ subunit
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