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Interleukin-31 receptor α subunit
- Molecular classification
- Type I cytokine receptor, gp130/IL-6 receptor family, Receptor
01
Overview
The IL-31 receptor α subunit (IL-31RA) is a type I cytokine receptor and a member of the gp130/IL-6 receptor family. It forms a heterodimeric complex with the oncostatin M receptor β subunit (OSMRβ) to mediate signaling in response to interleukin 31 (IL-31). It is involved in pruritus and inflammatory skin disorders.
- Other names
- IL31RACRLCRL3GPLGlmrNR10
02
Mechanism of action
IL-31RA forms a heterodimeric receptor with OSMRβ, and drugs targeting IL-31RA block IL-31 signaling, inhibiting downstream pathways like JAK/STAT, PI3K/AKT, and MAPK, reducing inflammation and itch.
03
Biological functions
Signal transductionImmune responsePruritus inductionHematopoiesis regulation
04
Disease associations
Atopic dermatitisPrurigo nodularisInflammationPruritic skin disorders
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