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Target intelligence / Profile preview
Interleukin 31 Receptor A (IL-31RA)
- Target
- IL-31RA
- Molecular classification
- Receptor, Cytokine Receptor
01
Overview
Interleukin-31 receptor A (IL-31RA) is a protein that forms part of the heterodimeric receptor complex for interleukin-31 (IL-31), together with oncostatin M receptor β (OSMRβ). This receptor complex is essential for mediating the biological effects of IL-31, a cytokine primarily produced by activated CD4+ T cells. Upon binding of IL-31, the receptor activates JAK/STAT, PI3K/AKT, and MAPK signaling pathways, resulting in transcriptional regulation affecting cell proliferation, differentiation, inflammation, pruritus transmission, and tissue remodeling. IL-31RA plays a crucial role in inflammatory diseases such as atopic dermatitis, prurigo nodularis, and airway hypersensitivity disorders.
02
Mechanism of action
Antibody-mediated neutralization of IL-31 or its receptor IL-31RA
03
Biological functions
Cytokine bindingCytokine receptor activityProtein kinase bindingTranscription coactivator activityRegulation of hematopoiesisModulation of immune responsesPruritus inductionSensory neuron growthInflammationTissue remodelingSignal transduction
04
Disease associations
Atopic dermatitisPrurigo nodularisAirway hypersensitivity disordersAsthmaAllergiesInflammatory bowel diseaseInflammatory diseases
05
Interacting drugs
Anti-IL-31 antibodies
1 more in the full profile.
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