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Target intelligence / Profile preview
Interleukin-31 Receptor Subunit Alpha (IL-31RA)
- Target
- IL-31RA
- Molecular classification
- Type I cytokine receptor, Transmembrane glycoprotein
01
Overview
IL-31 receptor subunit alpha (IL-31RA) is a type I cytokine receptor that forms part of the functional receptor complex for interleukin 31 (IL-31). It is encoded by the *IL31RA* gene and is expressed on various cell types, including immune cells, keratinocytes, dorsal root ganglia neurons, and some epithelial cells. The functional IL-31 receptor is a heterodimer composed of IL-31RA and Oncostatin M receptor beta subunit (OSMRβ). Binding of IL-31 to this heterodimeric complex triggers downstream signaling events, including activation of JAK/STAT, PI3K/AKT, and MAPK pathways. It plays a key role in mediating pruritus and regulating immune responses.
- Other names
- IL31RA
02
Mechanism of action
Nemolizumab is an anti-IL-31 receptor A antibody that blocks IL-31 signaling.
03
Biological functions
Signal transductionPruritus mediationImmune response regulationInflammatory response regulationHematopoiesis
04
Disease associations
Atopic dermatitisPrurigo nodularisPrimary localized cutaneous amyloidosis type 2Inflammatory bowel diseaseAirway hypersensitivity/AsthmaScleroderma/Systemic SclerosisChronic renal insufficiency-related pruritus
05
Interacting drugs
Nemolizumab
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