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Target intelligence / Profile preview
Interleukin-36 gamma (IL-36γ)
- Target
- IL-36γ
- Molecular classification
- Cytokine, Interleukin-1 superfamily
01
Overview
Interleukin-36 gamma (IL-36γ) is a pro-inflammatory cytokine belonging to the interleukin-1 family. It is primarily expressed in epithelial tissues, particularly in the skin, gut, and lung. IL-36γ binds to the IL-36 receptor (IL1RL2) and requires IL-1RAcP for signaling, leading to the activation of NF-κB and MAPK pathways and the production of pro-inflammatory cytokines and chemokines. It plays a critical role in innate immune responses and is strongly implicated in chronic inflammatory diseases such as psoriasis and inflammatory bowel disease. The activity of IL-36γ is specifically inhibited by the interleukin-36 receptor antagonist (IL-36Ra).
- Other names
- IL36GInterleukin 1 family member 9IL1F9
02
Mechanism of action
Inhibition of IL-36 receptor signaling by IL-36Ra
03
Biological functions
Pro-inflammatory mediatorActivates NF-kappa-B/MAPK pathwaysInnate immune responseStimulates dendritic cellsT cell proliferation
04
Disease associations
PsoriasisPsoriatic arthritisSystemic lupus erythematosusInflammatory bowel diseaseUlcerative colitisCrohn's diseaseSjögren's syndrome
05
Safety considerations
Excessive inflammationDysregulation can affect tissue inflammation dynamics
06
Interacting drugs
IL-36Ra (Interleukin-36 receptor antagonist)
07
Biomarkers
IL-36γ mRNA/protein levels in psoriatic lesions (biomarker for psoriasis diagnosis and differentiation from eczema)
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