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Target intelligence / Profile preview
Interleukin 36 Receptor (IL36R)
- Target
- IL36R
- Molecular classification
- Receptor, Interleukin-1 receptor family
01
Overview
Interleukin 36 Receptor (IL36R) is a member of the interleukin-1 receptor family and forms a heterodimeric receptor complex with IL-1RAcP. Activation by its agonists (IL-36α, IL-36β, IL-36γ) triggers pro-inflammatory signaling pathways, while antagonists (IL-36Ra, Interleukin-38) block receptor activation. IL36R is predominantly expressed in epithelial tissues and plays a key role in innate and adaptive immunity. Dysregulation of IL36R signaling is implicated in various inflammatory diseases, making it a therapeutic target for conditions such as psoriasis and inflammatory bowel disease.
- Other names
- IL-1 receptor-related protein 2IL-1Rrp2IL-1RL2
02
Mechanism of action
Agonist binding induces heterodimerization with IL-1RAcP, activating downstream NF-kB and MAPK signaling pathways. Antagonists block IL-1RAcP recruitment, preventing signal transduction.
03
Biological functions
Signal transductionImmune responsePro-inflammatory cytokine inductionHost defenseSkin homeostasisT cell proliferationT cell activation
04
Disease associations
InflammationPsoriasisPsoriatic arthritisInflammatory bowel diseaseSystemic lupus erythematosusSjögren's syndrome
05
Interacting drugs
Anti-IL-36α antibodies
1 more in the full profile.
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