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Target intelligence / Profile preview
Interleukin-4 Receptor (IL-4R)
- Target
- IL-4R
- Molecular classification
- Type I cytokine receptor, Receptor
01
Overview
The Interleukin-4 receptor (IL-4R) is a type I cytokine receptor complex that plays a critical role in type II immune responses and allergic inflammation. It exists in two forms: Type I (IL-4Rα + γc), which binds only IL-4, and Type II (IL-4Rα + IL-13Rα1), which binds both IL-4 and IL-13. Upon ligand binding, the receptor activates JAK kinases and STAT6, leading to gene expression changes involved in Th2 differentiation and IgE class switching. The soluble form of IL-4R acts as a decoy receptor, modulating immune response intensity. IL-4R is a therapeutic target for various allergic and inflammatory diseases.
- Other names
- IL4RCD124
02
Mechanism of action
Monoclonal antibodies bind to IL-4Rα or its ligands, blocking receptor activation and downstream signaling pathways like JAK/STAT6.
03
Biological functions
Immune regulationTh2 cell differentiationIgE antibody productionMacrophage activationSignal transduction
04
Disease associations
AsthmaEczemaAtopic dermatitisAllergic rhinitisAllergic diseasesAutoimmune disorders
05
Interacting drugs
Monoclonal antibodies against IL-4Rα
2 more in the full profile.
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