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Target intelligence / Profile preview
Interleukin 4 Receptor Alpha (IL-4Rα)
- Target
- IL-4Rα
- Molecular classification
- Type I cytokine receptor, Receptor, Transmembrane protein
01
Overview
Interleukin 4 receptor alpha (IL-4Rα) is the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that plays a central role in immune regulation. It is ubiquitously expressed on both innate and adaptive immune cells and mediates signaling for both IL-4 and IL-13, which are key cytokines in type II immune responses. Its main functions include promoting differentiation of T helper type 2 (Th2) cells, regulating IgE antibody production in B cells, and alternative activation of macrophages. Recent evidence shows neuronal expression modulates synaptic transmission within the CNS. Allelic variations have been associated with atopic diseases, making it a target for therapies modulating allergic inflammation.
- Other names
- IL4RInterleukin-4 Receptor Subunit AlphaIL4RA
02
Mechanism of action
Antibodies or antagonists binding to IL-4Rα, blocking IL-4 and IL-13 signaling.
03
Biological functions
Signal transductionImmune responseTh2 cell differentiationIgE antibody productionMacrophage activationSynaptic transmission modulation
04
Disease associations
Atopic diseasesAllergic rhinitisSinusitisAsthmaEczemaInflammationAutoimmune conditions
05
Safety considerations
Potential for immunosuppressionRisk of infectionsPotential alterations to neuronal function
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