Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Interleukin-4 Receptor Alpha Subunit (IL-4Rα)
- Target
- IL-4Rα
- Molecular classification
- Cytokine receptor, Type I transmembrane protein
01
Overview
The interleukin-4 receptor alpha subunit (IL-4Rα, also known as CD124) is a type I transmembrane protein that serves as the principal binding component for interleukin-4 (IL-4) and interleukin-13 (IL-13). It is ubiquitously expressed on both innate and adaptive immune cells and plays a crucial role in regulating humoral immunity and promoting Th2-type immune responses. Dysregulation of IL-4Rα is linked to atopic diseases.
- Other names
- CD124
02
Mechanism of action
Inhibition of IL-4 and IL-13 signaling by blocking IL-4Rα.
03
Biological functions
Signal transductionImmune responseTh2 differentiationIgE productionMacrophage activationHumoral immunity regulation
04
Disease associations
AsthmaAtopic dermatitisAllergic rhinitisSinusitisEczemaInflammation
Beyond the preview
Go deeper on Interleukin-4 Receptor Alpha Subunit (IL-4Rα).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Interleukin-4 Receptor Alpha Subunit (IL-4Rα).