Interleukin-4 receptor complex (IL-4R) (IL-4R)

The Interleukin-4 receptor (IL-4R) complex is a critical mediator of the Type 2 immune response, existing in two distinct forms: the Type I receptor (IL-4Rα and the common gamma chain) and the Type II receptor (IL-4Rα and IL-13Rα1) (Source: UniProt P24394). The Type I complex is primarily expressed on hematopoietic cells and responds specifically to IL-4, while the Type II complex is found on both hematopoietic and non-hematopoietic cells, responding to both IL-4 and IL-13 (Source: PubMed PMID: 30172252). These receptors play a pivotal role in driving Th2 cell differentiation, B-cell class switching to IgE, and the activation of alternative macrophages (Source: StatPearls, Interleukin-4). Dysregulation of IL-4R signaling is a hallmark of various allergic and inflammatory conditions, including asthma and atopic dermatitis (Source: NIH, National Institute of Allergy and Infectious Diseases). Therapeutic targeting of the IL-4Rα subunit, most notably by the monoclonal antibody dupilumab, effectively blocks the dual signaling of IL-4 and IL-13, providing significant clinical benefit in Type 2-driven diseases (Source: FDA, Dupixent Label).

Other names

IL-4 receptorCD124IL4RInterleukin-4 receptor alpha chainType I IL-4 receptorType II IL-4 receptor

Antagonism of the IL-4 receptor alpha subunit (IL-4Rα), which inhibits the signaling of both interleukin-4 (IL-4) and interleukin-13 (IL-13) pathways by preventing the formation of the functional receptor complexes (Source: PubMed PMID: 24582312).