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Target intelligence / Profile preview
Interleukin-4 Receptor Type II
- Molecular classification
- Cytokine Receptor, Interleukin Receptor, IL-2 receptor family
01
Overview
The interleukin-4 receptor type II (IL-4R type II) is a heterodimeric cell surface receptor composed of IL-4Rα and IL-13Rα1 subunits. It mediates the biological effects of IL-4 and IL-13, playing a central role in type 2 immune responses, including host defense against parasites, allergic inflammation, asthma, and tissue fibrosis. It is predominantly expressed on nonhematopoietic cells and myeloid cells. Upon ligand binding, it activates intracellular pathways such as STAT6, driving Th2-type immune responses. Therapeutics targeting this pathway aim to modulate excessive Th2-driven inflammation.
02
Mechanism of action
Modulation of Th2-driven inflammation
03
Biological functions
Signal transductionImmune responseAnti-parasite defenseRegulation of neutrophil activity
04
Disease associations
AllergiesAsthmaFibrotic disorders
05
Safety considerations
Potential for compromising host defense mechanisms
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