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Target intelligence / Profile preview
Interleukin 5 (IL‑5)
- Target
- IL‑5
- Molecular classification
- Cytokine, Interleukin
01
Overview
Interleukin 5 (IL‑5) is a cytokine critical in the regulation and activation of eosinophils and B cells. It promotes eosinophil maturation, proliferation, activation, survival, and migration. It also stimulates B cell growth and differentiation, increasing immunoglobulin secretion. IL-5 is a key mediator of eosinophilic inflammation and is implicated in asthma, allergic diseases, and autoimmunity. Therapeutics targeting IL-5 have shown efficacy in reducing bronchial mucosal eosinophilia and asthma symptoms.
02
Mechanism of action
Anti–IL‑5 monoclonal antibodies neutralize IL-5, preventing it from binding to its receptor on eosinophils, thus reducing eosinophil activation and survival.
03
Biological functions
Immune responseEosinophil maturationEosinophil proliferationEosinophil activationEosinophil survivalEosinophil migrationB cell growthB cell differentiationImmunoglobulin secretionRegulation of chronic inflammationLinks innate and adaptive immunity
04
Disease associations
AsthmaAllergic diseasesEosinophiliaAutoimmunity
05
Interacting drugs
Mepolizumab
1 more in the full profile.
06
Biomarkers
Eosinophil countIgA levels
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