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Target intelligence / Profile preview
Interleukin 5 Receptor Alpha Subunit (IL-5Rα)
- Target
- IL-5Rα
- Molecular classification
- Receptor, Cytokine Receptor, Type I cytokine receptor
01
Overview
The interleukin 5 receptor alpha subunit (IL-5Rα) is a receptor for interleukin-5 (IL-5), a cytokine critical for the development, activation, survival, and function of eosinophils. It forms a heterodimeric receptor complex with the common beta chain (βc), which is shared with the receptors for interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-5Rα is primarily expressed on eosinophils, basophils, and some B cells. Binding of IL-5 to IL-5Rα triggers intracellular signaling cascades, primarily via the JAK/STAT pathway, leading to the biological effects of IL-5. As a key regulator of eosinophil biology, IL-5Rα is a therapeutic target for eosinophil-mediated diseases, such as asthma and hypereosinophilic syndromes. Monoclonal antibodies and peptide antagonists targeting IL-5Rα are being developed to block IL-5 signaling and reduce eosinophil activity.
- Other names
- IL5RACD125
02
Mechanism of action
Antibody-mediated antagonism of IL-5Rα signaling; sequestration of IL-5Rα chains to prevent receptor assembly/dimerization.
03
Biological functions
Signal transductionEosinophil developmentEosinophil activationEosinophil survivalEosinophil adhesionEosinophil migrationEosinophil degranulationTissue survivalRegulation of allergic inflammation
04
Disease associations
AsthmaHypereosinophilic diseasesAllergic inflammation
05
Safety considerations
Potential for immunosuppressionRisk of infections
06
Interacting drugs
Benralizumab
2 more in the full profile.
07
Biomarkers
Eosinophil countsIL-5Rα levels
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