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Target intelligence / Profile preview
Interleukin-5 Receptor Subunit Alpha (IL-5Rα)
- Target
- IL-5Rα
- Molecular classification
- Type I cytokine receptor family, Receptor
01
Overview
Interleukin-5 receptor subunit alpha (IL-5Rα), also known as CD125, is a cytokine receptor subunit that specifically binds interleukin-5 (IL-5). It forms part of the heterodimeric IL-5 receptor complex, which is essential for mediating the biological effects of IL-5, particularly in eosinophil biology and related immune responses. Dysregulation or overexpression of this receptor contributes significantly to hypereosinophilic diseases—including allergic asthma—by promoting excessive eosinophil activity. Therapeutically targeting either the ligand or its specific alpha-receptor has shown benefit in treating these conditions.
- Other names
- IL5RACD125
02
Mechanism of action
Monoclonal antibodies against IL-5Rα block IL-5 binding and downstream signaling, preventing eosinophil activation and survival.
03
Biological functions
Signal transductionEosinophil maturationEosinophil recruitmentEosinophil activationEosinophil survivalImmune response
04
Disease associations
AsthmaAllergyHypereosinophilic syndromes
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