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Target intelligence / Profile preview
Interleukin 6 (IL-6)
- Target
- IL-6
- Molecular classification
- Cytokine, Interleukin
01
Overview
Interleukin 6 (IL-6) is a multifunctional cytokine that acts as both a pro-inflammatory and anti-inflammatory mediator. It plays critical roles in immune regulation, inflammation, hematopoiesis, metabolism, neural development, and cancer biology. IL-6 is produced in response to infections or tissue injuries and its dysregulation contributes to chronic inflammatory diseases.
- Other names
- IL6
02
Mechanism of action
Monoclonal antibodies targeting IL-6 or its receptor (IL-6R) block both classical signaling through membrane-bound receptors and trans-signaling via soluble receptors, thus inhibiting downstream inflammatory pathways.
03
Biological functions
Immune regulationInflammationHematopoiesisMetabolismNeural developmentAcute phase responseB cell growthT cell differentiationSignal transduction
04
Disease associations
Rheumatoid arthritisJuvenile idiopathic arthritisChronic inflammatory diseasesSepsisCOVID-19CancerAutoimmunityInflammation
05
Safety considerations
ImmunosuppressionIncreased risk of infectionPotential for serious adverse events (e.g., gastrointestinal perforation, liver enzyme elevations)
06
Interacting drugs
Clazakizumab
4 more in the full profile.
07
Biomarkers
Elevated serum levels in severe infection/inflammationCOVID-19 prognosisCancer prognosisRheumatic disease activity
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