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Target intelligence / Profile preview
Interleukin 6 antisense RNA 1 (IL6-AS1)
- Target
- IL6-AS1
- Molecular classification
- Other (Long noncoding RNA, lncRNA)
01
Overview
Interleukin 6 antisense RNA 1 (IL6-AS1) is a long noncoding RNA (lncRNA) that is transcribed antisense to the IL6 gene locus. Unlike canonical therapeutic targets such as receptors or enzymes, IL6-AS1 does not encode a protein but regulates the expression of interleukin 6 (IL-6) at both transcriptional and post-transcriptional levels[2][4]. In the cytoplasm, IL6-AS1 acts as an endogenous sponge, binding to microRNA miR-149-5p and stabilizing IL-6 mRNA, leading to increased IL-6 production. In the nucleus, IL6-AS1 recruits early B-cell factor 1 (EBF1) to the IL-6 promoter, promoting histone modifications (H3K4 methylation, H3K27 acetylation) to enhance IL-6 transcription. IL6-AS1 is upregulated in chronic obstructive pulmonary disease and is linked to airway inflammation through multiple mechanisms that augment IL-6 levels[2][4]. There is currently no evidence that IL6-AS1 directly interacts with pharmacological agents or serves as a therapeutic target, but its function as a regulator of cytokine expression suggests emerging translational interest.
- Other names
- IL6-AS1IL6 antisense RNA 1long noncoding RNA IL6-AS1
02
Biological functions
Inflammatory response regulationRegulation of gene expressionEpigenetic modulationCytokine induction
03
Disease associations
InflammationChronic obstructive pulmonary diseasePotential cancer relevance (requires further study)
04
Safety considerations
Potential for widespread impact on inflammatory processesprecise therapeutic targeting of lncRNAs remains technically challenging
05
Biomarkers
Increased expression in airway inflammation and chronic obstructive pulmonary disease (COPD)
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