Interleukin-6 cytokine family signal transducer (IL6ST (also known as gp130, CD130))

The **interleukin-6 cytokine family signal transducer (IL6ST, gp130)** is a transmembrane glycoprotein that functions as a shared signal transducing receptor subunit for members of the IL-6 cytokine family, including interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1)[2][3][4][5]. Upon ligand binding to these cytokines’ specific receptors, gp130 dimerizes and initiates downstream intracellular signaling, particularly via the Janus kinase (JAK)/STAT pathway, to mediate processes such as inflammation, immune response, and cell proliferation[2][4][5]. Dysregulation of gp130 signaling is implicated in inflammatory diseases, cancers, and autoimmune disorders.

Other names

Glycoprotein 130gp130CD130Interleukin-6 receptor subunit betaMembrane glycoprotein 130Oncostatin M receptorsGP130IL-6RB

Monoclonal antibodies target IL-6 or its receptor, inhibiting the formation of the IL-6/IL-6 receptor/gp130 signaling complex and blocking downstream JAK/STAT signaling[2].