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Interleukin 6 receptor alpha (IL-6Rα)
- Target
- IL-6Rα
- Molecular classification
- Type I cytokine receptor, Receptor
01
Overview
Interleukin 6 receptor alpha (IL-6Rα) is a type I cytokine receptor that mediates the biological effects of interleukin 6 (IL-6). The functional receptor complex consists of IL-6Rα and the signal-transducing component gp130. IL-6Rα exists in both membrane-bound and soluble forms, with the soluble form capable of activating cells that do not express the membrane-bound receptor. Dysregulation of IL-6Rα is implicated in various diseases, including autoimmune disorders and cancer, making it a therapeutic target.
- Other names
- IL6RCD126
02
Mechanism of action
Monoclonal antibody or small molecule antagonist that blocks IL-6 signaling by binding to IL-6Rα or its downstream signaling components.
03
Biological functions
Immune regulationInflammationHematopoiesisBone metabolismOncogenesisRegulating cell growth and differentiationPromoting immune responsesB-cell maturation into plasma cellsT-helper cell differentiation toward Th17 lineageInhibition of Th1 polarizationEnhancement of cytolytic T-cell function
04
Disease associations
Multiple myelomaAutoimmune disorders (e.g., rheumatoid arthritis)Prostate cancerChronic inflammatory conditions
05
Interacting drugs
Tocilizumab
2 more in the full profile.
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