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Target intelligence / Profile preview
Interleukin 6 Receptor Alpha Subunit (IL6R)
- Target
- IL6R
- Molecular classification
- Type I cytokine receptor, Receptor
01
Overview
The Interleukin 6 receptor alpha subunit (IL6R), also known as CD126, is a type I cytokine receptor and a key component of the IL-6 signaling pathway. The functional IL-6 receptor complex consists of the IL-6 receptor alpha subunit (IL6R/CD126) and glycoprotein 130 (gp130/IL6ST), which acts as the signal transducer. IL6R mediates cellular responses to interleukin-6, which regulates cell growth, differentiation, immune response, acute-phase reactions, and hematopoiesis. There are both membrane-bound and soluble forms of IL6R, mediating classic and trans-signaling, respectively. Dysregulated production or function implicated in diseases such as multiple myeloma and autoimmune diseases.
- Other names
- CD126Interleukin-6 receptor subunit alpha
02
Mechanism of action
Monoclonal antibody against human IL-6 receptor; small molecule antagonist.
03
Biological functions
Immune regulationAcute phase responseHematopoiesisCell growth regulationCell differentiation
04
Disease associations
Multiple myelomaAutoimmune diseasesRheumatoid arthritisProstate cancerCastleman's diseasePsoriasisPost-menopausal osteoporosisInflammation
05
Interacting drugs
Tocilizumab
2 more in the full profile.
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