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Interleukin-6 Receptor Family
- Molecular classification
- Cytokine receptor, Type I cytokine receptor, Receptor
01
Overview
The Interleukin-6 (IL-6) receptor family is a group of cytokine receptors that mediate the biological effects of the IL-6 family of cytokines. These receptors are characterized by their use of a common signal-transducing subunit, gp130 (IL6ST), which is essential for downstream signaling. Family members include IL6R, IL11R, CNTFR, LIFR, OSMR, IL27RA, and IL31RA. Signaling is mediated through the JAK/STAT, Ras/Raf/MAPK, and PI3K/PKB pathways. The IL-6 family regulates diverse physiological processes including hepatic acute phase response, B-cell stimulation and differentiation, balance between regulatory and effector T cells, metabolic regulation, and neural functions. Blockade or modulation of this family's signaling has therapeutic potential in autoimmune diseases.
02
Mechanism of action
Monoclonal antibodies targeting IL-6 or IL-6R block downstream signaling.
03
Biological functions
Immune regulationInflammation controlHematopoiesisNeural developmentAcute phase responseB-cell stimulation and differentiationRegulation of T cell balanceMetabolic regulation
04
Disease associations
Autoimmune diseasesInflammatory diseasesCancerInfections
05
Safety considerations
Increased susceptibility to infectionsMetabolic side effects
06
Interacting drugs
Tocilizumab
4 more in the full profile.
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