Interleukin 6 receptor pseudogene 1 (IL6RP1)

Interleukin 6 receptor pseudogene 1 (IL6RP1) is a non-coding pseudogene with sequence similarity to the interleukin 6 receptor alpha gene (IL6Rα). It is located on chromosome 9 at q22.2 and, like other pseudogenes, is considered non-functional for protein expression, meaning it does not yield an active receptor or protein[1][3]. As a pseudogene, IL6RP1 does not participate directly in cytokine signaling, immune response, or disease pathogenesis. Instead, any potential roles are likely limited to possible post-transcriptional gene regulation or serving as a competitive endogenous RNA ("ceRNA"), though this is unconfirmed and not well established in the literature[1][3]. Unlike the canonical Interleukin 6 receptor (IL6R or CD126), which is a major therapeutic target implicated in inflammatory and autoimmune diseases and targeted by drugs like tocilizumab, IL6RP1 is not a target for drug development and is not relevant in clinical pharmacology or disease treatment contexts[2][3][1].

Other names

IL6RL1Interleukin 6 receptor-like 1IL6RP1