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Target intelligence / Profile preview
Interleukin-6 Receptor Subunit Alpha (IL6R)
- Target
- IL6R
- Molecular classification
- Type I cytokine receptor, Receptor, Single-pass transmembrane protein
01
Overview
The interleukin-6 receptor subunit alpha (IL6R), also known as CD126, is a type I cytokine receptor and forms part of the functional IL-6 receptor complex. It binds interleukin 6 (IL‑6) with low affinity; signal transduction requires association with gp130/IL‑6ST. IL6R exists in both membrane-bound and soluble forms. It regulates immune response, acute-phase reactions, hematopoiesis, cell growth/differentiation, and tissue regeneration and is implicated in multiple diseases including autoimmune diseases and cancer. Therapeutic targeting includes monoclonal antibodies and small molecule antagonists.
- Other names
- CD126IL-6R alphaIL6RA
02
Mechanism of action
Monoclonal antibody or small molecule antagonist binding to IL-6R, blocking IL-6 signaling and subsequent downstream pathway activation, such as JAK/STAT
03
Biological functions
Immune response regulationAcute-phase reaction regulationHematopoiesisCell growth and differentiationTissue regenerationSignal transduction
04
Disease associations
Autoimmune diseasesMultiple myelomaProstate cancerRheumatoid arthritisCastleman’s diseasePsoriasisPost-menopausal osteoporosisInflammation
05
Interacting drugs
Tocilizumab
3 more in the full profile.
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