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Target intelligence / Profile preview
Interleukin-6 Receptor Subunit Beta (IL6RB)
- Target
- IL6RB
- Molecular classification
- Receptor, Transmembrane protein, Cytokine receptor subunit
01
Overview
Interleukin-6 receptor subunit beta (IL6RB), also known as gp130, is a critical signal-transducing component shared by several cytokine receptors, including the receptor for interleukin-6 (IL-6). Upon ligand binding, gp130 dimerizes and activates downstream JAK/STAT and MAPK pathways, leading to diverse biological effects. Dysregulation of the IL-6/gp130 pathway is implicated in various diseases, making it a therapeutic target.
- Other names
- gp130IL6ST
02
Mechanism of action
Selective antagonists targeting the IL-6/gp130 pathway
03
Biological functions
Signal transductionImmune response regulationHematopoiesisBone metabolismNeuronal survival/differentiationAstrocyte differentiation
04
Disease associations
Autoimmune disordersRheumatoid arthritisSystemic inflammatory conditionsCancer
05
Safety considerations
Potential for immunosuppressionOff-target effects due to shared signaling pathways with other cytokines
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