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Interleukin-6 secretion

Overview

Interleukin-6 secretion is the process by which cells, predominantly immune cells like macrophages and T cells, release the cytokine interleukin-6 in response to stimuli such as infection, injury, or inflammation. IL-6 acts via classic or trans-signaling through its receptor complex, leading to diverse effects on immune modulation, inflammation, and acute phase responses. Dysregulation of IL-6 secretion is implicated in a wide range of pathological conditions, especially chronic inflammatory diseases and cancer.

Biological functions

Immune responseInflammationHematopoiesisAcute phase response

Disease associations

InflammationCancerAutoimmune diseaseInfectious disease

Safety considerations

Targeting this process could suppress host defense and increase infection risk, as IL-6 is central in immune response

Biomarkers

Increased IL-6 concentrations in serum (used as a biomarker of inflammation and therapeutic response)

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