Target intelligence / Profile preview

Interleukin 6 signal transducer pseudogene 1 (IL6STP1)

Target
IL6STP1
Molecular classification
Pseudogene, Other
01

Overview

Interleukin 6 signal transducer pseudogene 1 (IL6STP1) is a processed pseudogene located in the human genome. Unlike the functional interleukin 6 signal transducer (IL6ST/gp130), which mediates signaling for a family of cytokines including interleukin 6 and interleukin 11, IL6STP1 does not code for a functional protein and is not involved in canonical cytokine receptor signaling. Pseudogenes such as IL6STP1 may, in rare cases, regulate expression of the parent gene or related genetic elements via RNA-mediated mechanisms, but there is no experimental evidence indicating any such function for IL6STP1. It is not considered a therapeutic target, nor is it relevant for drug development, biomarker research, or clinical safety[1][3][5][7].\n\nKey clarification: You may be seeking IL6ST (interleukin 6 signal transducer, "gp130"), which is a cell-surface cytokine receptor and bona fide therapeutic target involved in immune signaling and cancer, but IL6STP1 is only a pseudogene of IL6ST[1][7]. If you need information on the true interleukin 6 signal transducer (IL6ST or gp130), please clarify.

Other names
IL6STP
02

Biological functions

Likely none as a protein product; pseudogenes typically do not encode functional proteinsSome pseudogenes can regulate gene expression indirectly (e.g., by acting as decoys for miRNAs or other regulatory elements), but no evidence specific to IL6STP1 was identified
03

Disease associations

OtherOne database associated IL6STP1 generically with "inflammatory bowel disease," but this is likely bioinformatic noise or misattribution, as no functional or clinical role is established

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