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Target intelligence / Profile preview
Interleukin-7 Receptor (IL-7R)
- Target
- IL-7R
- Molecular classification
- Type I cytokine receptor
01
Overview
The interleukin-7 receptor (IL-7R) is a cell surface protein crucial for immune system development and function. It is a heterodimer composed of two subunits: IL-7 receptor alpha chain (IL-7Rα, also known as CD127) and the common gamma chain (γc). It plays essential role in immune system development by regulating proliferation/survival signals required for normal maturation/functioning of both B cells and T cells. Defects lead to profound immunodeficiencies or contribute to autoimmunity/cancer depending on context.
- Other names
- CD127
02
Mechanism of action
N/A
03
Biological functions
Lymphocyte developmentLymphocyte homeostasisV(D)J recombinationSignal transductionAnti-apoptosisCell survivalCell proliferation
04
Disease associations
Severe Combined Immunodeficiency (SCID)T-cell acute lymphoblastic leukemiaMultiple sclerosisRheumatoid arthritisJuvenile idiopathic arthritisImmunodeficiencyAutoimmunityCancer
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