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Target intelligence / Profile preview
Interleukin 7 Receptor Alpha (IL-7Rα)
- Target
- IL-7Rα
- Molecular classification
- Type I cytokine receptor, Receptor
01
Overview
Interleukin 7 receptor alpha (IL-7Rα), also known as CD127, is a type I cytokine receptor subunit that forms part of the interleukin-7 (IL-7) receptor and the thymic stromal lymphopoietin (TSLP) receptor. It is expressed on various immune cells and is essential for lymphocyte development, survival, and homeostasis. Dysregulation of IL-7Rα is implicated in several diseases, including SCID, ALL, and autoimmune disorders.
- Other names
- CD127Cluster of Differentiation 127Interleukin-seven receptor subunit alpha
02
Mechanism of action
Modulation of IL-7 and TSLP signaling pathways via receptor agonism or antagonism
03
Biological functions
Signal transductionImmune responseCell proliferationCell survivalLymphocyte developmentV(D)J recombinationHomeostasis
04
Disease associations
Severe Combined Immunodeficiency (SCID)Acute Lymphoblastic Leukemia (ALL)Multiple SclerosisRheumatoid ArthritisJuvenile Idiopathic ArthritisAutoimmunity
05
Safety considerations
Potential for immune dysregulation and autoimmunityRisk of cytokine storm upon excessive stimulation
06
Biomarkers
IL-7Rα expression levels in lymphocytes for diagnosis of immune disordersMutations in IL7R gene for predicting leukemia risk
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