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Target intelligence / Profile preview
Interleukin 7 Receptor Alpha Chain (IL-7Rα)
- Target
- IL-7Rα
- Molecular classification
- Type I cytokine receptor, Single-pass transmembrane protein
01
Overview
The Interleukin 7 receptor alpha chain (IL-7Rα), also known as CD127, is a type I cytokine receptor subunit that forms part of the functional interleukin-7 receptor complex and also serves as a component of the thymic stromal lymphopoietin (TSLP) receptor. It is essential for the normal development, survival, proliferation, and homeostasis of T cells and B cell progenitors. Upon ligand binding, it triggers downstream pathways critical for lymphocyte proliferation via PI3K/AKT signaling. Mutations in *IL7R* can lead to severe combined immunodeficiency.
- Other names
- CD127
02
Mechanism of action
Modulation of IL-7 and TSLP signaling, affecting lymphocyte proliferation and differentiation via JAK/STAT and PI3K/AKT pathways
03
Biological functions
Lymphocyte developmentLymphocyte survivalLymphocyte proliferationLymphocyte differentiationSignal transductionHomeostasis
04
Disease associations
Severe combined immunodeficiencyAutoimmune diseasesImmunodeficienciesCancer
05
Safety considerations
Potential for affecting other cytokine systems sharing γc subunitsAltered lymphocyte homeostasis
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