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Target intelligence / Profile preview
Interleukin 7 Receptor Alpha Subunit (IL-7Rα)
- Target
- IL-7Rα
- Molecular classification
- Type I cytokine receptor, Receptor, Single-pass transmembrane protein
01
Overview
The interleukin-7 receptor alpha subunit (IL-7Rα), also known as CD127, is a type I cytokine receptor. It serves as a critical component of two distinct heterodimeric receptors: the interleukin-7 receptor (with the common gamma chain, γc/CD132) and the thymic stromal lymphopoietin (TSLP) receptor (with TSLPR). It is expressed primarily on lymphoid lineage cells and plays a crucial role in lymphocyte development, survival, and homeostasis. Altered expression/function is implicated in various diseases, including immunodeficiencies, autoimmunity, and cancer, making it a potential therapeutic target.
- Other names
- CD127IL7R
02
Mechanism of action
Targeted therapeutics may exploit this axis for cancer immunotherapy. Soluble form can modulate immune responses by acting as a decoy or regulator in circulation.
03
Biological functions
Signal transductionImmune responseCell proliferationCell survivalT cell developmentLymphocyte homeostasis
04
Disease associations
ImmunodeficiencyAutoimmunityCancer
05
Safety considerations
Potential for immune-related adverse events in therapies targeting IL-7RαAltered immune reconstitution after bone marrow transplantation
06
Biomarkers
Low surface expression distinguishes regulatory from conventional human CD4+ T cellsPredictive marker in cancer immunotherapy
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