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Target intelligence / Profile preview
Interleukin-7 Receptor Subunit Alpha (IL-7Rα)
- Target
- IL-7Rα
- Molecular classification
- Type I cytokine receptor family, Receptor
01
Overview
Interleukin-7 receptor subunit alpha (IL-7Rα), also known as CD127, is a type I cytokine receptor essential for the development and homeostasis of T and B lymphocytes. It forms a heterodimer with the common gamma chain (γc/CD132) to create the functional IL-7 receptor. Upon binding of IL-7, the receptor complex activates intracellular signaling pathways, primarily the JAK/STAT pathway, leading to cell survival and proliferation. IL-7Rα also participates in the TSLP receptor complex and is implicated in various diseases, including SCID, autoimmune disorders, and leukemia.
- Other names
- CD127IL-7 receptor alpha chainIL-7RA
02
Mechanism of action
Ligand binding (IL-7 or TSLP) to the IL-7Rα/γc heterodimer activates the JAK/STAT signaling pathway, promoting cell survival and proliferation. Receptor endocytosis regulates signaling duration and receptor availability.
03
Biological functions
Lymphocyte developmentLymphocyte homeostasisSignal transductionImmune responseCell proliferationCell survival
04
Disease associations
Severe Combined Immunodeficiency (SCID)Autoimmune DiseasesAcute Lymphoblastic Leukemia
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