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Target intelligence / Profile preview
Interleukin 8 Receptor Beta (CXCR2)
- Target
- CXCR2
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
CXCR2, also known as Interleukin 8 receptor beta (IL8RB), is a member of the G protein-coupled receptor (GPCR) family and functions primarily as a chemokine receptor. It plays key roles in immune response and inflammation, mediating neutrophil migration and angiogenesis. Dysregulation has been implicated in various diseases including autoimmune disorders, chronic inflammatory conditions, cancer, and atherosclerosis.
- Other names
- IL8RBC-X-C chemokine receptor type 2GRO/MGSA receptor
02
Mechanism of action
Antibodies against CXCR2 can inhibit neutrophil recruitment/inflammation.
03
Biological functions
Immune responseInflammationAngiogenesisChemotaxisSignal transduction
04
Disease associations
Autoimmune disordersChronic inflammatory conditionsCancerAtherosclerosisHematological traits
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