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Target intelligence / Profile preview
Interleukin 9 Receptor (IL-9R)
- Target
- IL-9R
- Molecular classification
- Type I cytokine receptor
01
Overview
The Interleukin 9 Receptor (IL-9R) is a type I cytokine receptor composed of an alpha chain (IL-9Rα) and the common gamma chain (γc). It is the primary receptor for Interleukin 9 (IL-9), a pleiotropic cytokine involved in the regulation of immune responses, particularly in Th2, Th17, Treg, mast cells, NKT cells, and ILC2s. IL-9R activation triggers intracellular signaling pathways like JAK-STAT, MAP kinase, and PI3K, influencing cellular proliferation, differentiation, and survival. Dysregulation of IL-9/IL-9R signaling has been implicated in diseases such as asthma, Hodgkin's lymphoma, and melanoma.
- Other names
- CD129IL9Rαinterleukin 9 receptor alpha chain
02
Biological functions
Signal transductionRegulation of proliferationRegulation of differentiationApoptosis preventionImmune response
03
Disease associations
AsthmaHodgkin's lymphomaMelanoma
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