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Target intelligence / Profile preview
Interleukin Receptor (IL-R)
- Target
- IL-R
- Molecular classification
- Receptor, Cytokine Receptor, Single-pass transmembrane protein, Type I cytokine receptor family, Type II cytokine receptor family
01
Overview
Interleukin receptors are a family of cell surface and soluble proteins that bind interleukins, mediating immune and inflammatory responses. They are characterized by immunoglobulin-like extracellular domains and intracellular signaling domains like the TIR domain. Activation leads to downstream kinase cascades and transcription factor activation. Dysregulation is implicated in various diseases, making them therapeutic targets.
- Other names
- IL ReceptorInterleukin Receptor Family
02
Mechanism of action
Receptor antagonist; binds to interleukin receptors and blocks interleukin binding.
03
Biological functions
Signal transductionImmune responseInflammationCell proliferationCell differentiationHematopoiesis
04
Disease associations
Autoimmune disordersCardiovascular diseaseChronic inflammationCancerMyocardial infarctionMyocarditis
05
Safety considerations
ImmunosuppressionIncreased risk of infection
06
Interacting drugs
Anakinra
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