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Target intelligence / Profile preview
Intermediate conductance calcium-activated potassium channel protein 4 (KCa3.1)
- Target
- KCa3.1
- Molecular classification
- Ion channel, Potassium channel, Calcium-activated potassium channel
01
Overview
The intermediate conductance calcium-activated potassium channel protein 4 (KCa3.1) is a voltage-independent potassium channel activated by intracellular calcium. Activation leads to potassium efflux, resulting in membrane hyperpolarization, which is crucial for regulating cell volume, immune cell function (particularly T cell proliferation and activation), and other cellular processes. It is a therapeutic target for immune disorders and potentially cancer. The channel is blocked by clotrimazole and charybdotoxin but not significantly affected by apamin or iberiotoxin.
- Other names
- IK1IKCA1KCA4SK4hIKCa1hKCa4hSK4IKDHS2
02
Mechanism of action
Channel blocker; prevents potassium efflux, leading to membrane depolarization and reduced calcium influx.
03
Biological functions
Potassium ion transportCell volume regulationImmune response modulationT cell activationPositive regulation of T cell receptor signaling pathway
04
Disease associations
InflammationAutoimmune diseasesCancer (potential role in proliferation/migration)
05
Safety considerations
Potential for immunosuppressionOff-target effects on other potassium channelsCardiovascular effects due to altered potassium homeostasis
06
Interacting drugs
Charybdotoxin
1 more in the full profile.
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