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Target intelligence / Profile preview
Intermediate filament family orphan 2 (IFFO2)
- Target
- IFFO2
- Molecular classification
- Intermediate filament protein, Cytoskeletal structural protein
01
Overview
IFFO2 encodes a protein of the intermediate filament superfamily, essential for maintenance of cytoskeletal integrity and structural support within cells[7][1][3]. Its function appears to involve mechanical stability and regulation of cell morphology, consistent with other intermediate filaments[3][5]. A circular RNA derived from the IFFO2 locus (circ_IFFO2) is downregulated in cutaneous squamous cell carcinoma, implying possible roles in post-transcriptional regulation and cancer progression[1]. In livestock, genetic association studies suggest involvement in oxidative stress response and muscle control, potentially impacting feed efficiency[1]. No direct therapeutic, drug-targeting, or receptor-mediated roles are established for IFFO2 at present, and specific molecular functions remain under investigation.
- Other names
- Intermediate filament family orphan 2IFFO2IFFO2_HUMAN (UniProt)GC01M019106GC01M019230GC01M017474
02
Biological functions
Structural organization of cytoskeletonRegulation of cell morphology and mechanical stabilityModulation of RNA networks (suggested by circular RNA derived from IFFO2 locus in skin)Potential role in feed efficiency and muscle control (in livestock)
03
Disease associations
Cancer (dysregulation in cutaneous squamous cell carcinoma via circ_IFFO2)Possible involvement in metabolic and muscle-related traits in livestock
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