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Internal heat accumulation refers to the process by which heat is generated within an organism or system (such as the human body during physical exertion or a malfunctioning cooling process) and is not adequately dissipated, leading to an increase in core temperature. In humans and animals, this can occur due to environmental heat exposure, increased metabolic activity, medical conditions (such as during hemodialysis), or insufficient heat removal mechanisms like sweating or blood flow adjustments[1][2][3][7][9]. Internal heat accumulation is not a receptor, enzyme, protein, or classical therapeutic "target," but a *biophysiological state* that may contribute to clinical syndromes like heat exhaustion and heat stroke[1][7][9]. In traditional Chinese medicine, it can also refer to a syndrome of subjective or observed increased internal body heat, but this does not correspond to a defined biomedical molecule or receptor[4].
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