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Internal Limiting Membrane (ILM)
- Target
- ILM
- Molecular classification
- Extracellular Matrix, Basement Membrane
01
Overview
The internal limiting membrane (ILM) is the innermost boundary of the retina, forming a distinct interface between the retina and the vitreous body. It is a thin, transparent, acellular structure primarily composed of extracellular matrix proteins and serves as a true basement membrane. It plays roles in retinal development, acts as a barrier to substances moving from the vitreous into the retina, and is clinically relevant in the context of retinal diseases and surgical interventions.
- Other names
- Inner Limiting Membranemembrana limitans interna
02
Mechanism of action
N/A
03
Biological functions
Developmental scaffoldBarrier functionStructural supportMolecular signaling
04
Disease associations
Internal Limiting Membrane Dystrophy (ILMD)Macular holeMacular pucker
05
Safety considerations
Potential damage during ILM peelingBarrier to drug delivery and gene therapyComplications related to surgical removal
06
Interacting drugs
Anti-VEGF agents (indirectly via barrier function)
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