Intersectin-1 (ITSN1)

Intersectin-1 is a multi-domain, cytoplasmic membrane-associated scaffold protein encoded by the ITSN1 gene. It acts as an adaptor linking endocytic membrane trafficking with the actin cytoskeleton and coordinates the formation of clathrin-coated vesicles, synaptic vesicle recycling, and various signal transduction pathways[1][3][7]. ITSN1 exists in long (ITSN1-L) and short (ITSN1-S) isoforms due to alternative splicing, with some isoforms serving as guanine nucleotide exchange factors (GEFs) for small GTPases like Cdc42[2][5]. The protein is involved in neuronal development, dendritic spine morphology, and interacts with multiple partners such as dynamin, CDC42, EPS15, and endophilin, integrating endocytic processes with actin cytoskeleton dynamics and signaling[1][3][4][5][7]. Misregulation or mutation of ITSN1 has been linked to cancer progression and some neurodegenerative diseases, including Alzheimer's disease and Down syndrome[3][5]. There are currently no drugs directly targeting Intersectin-1, and it is not considered a traditional therapeutic receptor, enzyme, or transporter.

Other names

Intersectin-1ITSN1SH3 domain-containing protein 1ASH3D1ASH3P17human intersectin-SH3 domain-containing protein SH3P17Src homology 3 domain-containing proteinMGC134948MGC134949