Intersectin-2 (ITSN2)

Intersectin-2 is a cytoplasmic, multi-domain scaffold and adaptor protein that plays a central role in coordinating clathrin-mediated endocytosis, vesicular trafficking, and actin cytoskeleton reorganization[1][2][3][5][6]. It contains SH3 domains, EH domains, a coiled-coil domain, and—depending on the isoform—a Dbl homology (DH) domain, Pleckstrin homology (PH) domain, and C2 domain, granting it broad protein–protein interaction potential[2][3]. Intersectin-2 regulates clathrin-coated vesicle nucleation, maturation, and budding, promoting internalization of various receptors, including the epidermal growth factor receptor, tetraspanin complexes, and T cell receptor machinery[1][2][5][6]. It links endocytic events to cytoskeletal remodeling via activation of actin regulatory proteins such as Cdc42, WASP, and N-WASP, which is crucial for immune cell functions, dendritic formation in melanocytes, meiotic division in oocytes, and cellular polarity[1][2][5]. Intersectin-2 undergoes post-translational modifications (e.g., tyrosine phosphorylation) and acts as a node for integration of endocytosis and intracellular signaling pathways. While not a typical therapeutic target like a receptor or enzyme, it is fundamental for cellular homeostasis, with aberrant regulation implicated in various diseases including cancer and neurodegeneration[1][3][5]. There are currently no known drugs that target ITSN2 directly.

Other names

PRO2015SH3D1BSH3P18SWASWAPKIAA1256SH3 domain-containing protein 1BSH3P18-like WASP-associated proteinSH3 domain protein 1BSH3P18-like WASP associated proteinintersectin-2