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Target intelligence / Profile preview
Matrix metalloproteinase-1 (MMP-1)
- Target
- MMP-1
- Molecular classification
- Enzyme, Zinc-dependent endopeptidase, Matrix metalloproteinase
01
Overview
Matrix metalloproteinase-1 (MMP-1), also known as interstitial collagenase or fibroblast collagenase, is a zinc-dependent endopeptidase responsible for the degradation of extracellular matrix components, especially collagens. It plays a role in tissue remodeling, wound healing, and bone formation. Dysregulated MMP-1 activity contributes to diseases such as cancer, arthritis, and cardiovascular disease. Beyond ECM turnover, MMP-1 is involved in platelet activation and intracellular signaling.
- Other names
- Interstitial collagenaseFibroblast collagenase
02
Mechanism of action
Inhibition of MMP-1 enzymatic activity to prevent ECM degradation.
03
Biological functions
Tissue remodelingECM degradationWound healingBone formationRegulation of thrombotic eventsIntracellular signaling
04
Disease associations
Cancer metastasis/invasionRheumatoid arthritisAtherosclerosisAneurysm formationLiver fibrosis
05
Safety considerations
Potential for off-target effects due to the broad substrate specificity of MMPs.Impaired wound healing if MMP-1 activity is excessively inhibited.Musculoskeletal side effects
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