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Target intelligence / Profile preview
Intervertebral Disc Extracellular Matrix (IVD ECM)
- Target
- IVD ECM
- Molecular classification
- Extracellular Matrix, Structural protein, Proteoglycan, Glycoprotein
01
Overview
The intervertebral disc extracellular matrix (IVD ECM) is a complex network of proteins, proteoglycans, and water that provides structural support and mediates cell function within the intervertebral disc. It is composed primarily of collagen types I and II, aggrecan, and other proteoglycans. Degradation of the IVD ECM is a major contributor to intervertebral disc degeneration (IVDD), leading to pain and disability. Therapeutic strategies aim to regenerate the IVD ECM by stimulating endogenous repair mechanisms, delivering exogenous ECM components, and inhibiting matrix degradation.
- Other names
- Intervertebral Disc MatrixIVD MatrixDisc Extracellular MatrixDisc Matrix
02
Mechanism of action
ECM regeneration aims to restore the structural and functional integrity of the intervertebral disc by promoting proteoglycan and collagen synthesis, inhibiting matrix degradation enzymes, and providing a supportive scaffold for cell attachment and growth.
03
Biological functions
Load bearingCompression resistanceTensile strengthCell adhesionCell signalingTissue homeostasisNutrient diffusion
04
Disease associations
Intervertebral Disc DegenerationBack painSpinal StenosisSpondylolisthesisOsteoarthritis
05
Safety considerations
Immunogenicity of biomaterialsOff-target effects of growth factorsFibrosisCalcificationInfectionLimited long-term efficacyDifficulty in achieving complete ECM regeneration
06
Interacting drugs
BMP7
6 more in the full profile.
07
Biomarkers
AggrecanCollagen type IICollagen type IMMP levelsADAMTS levelsTIMP levelsWater contentDisc height
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